Senior/Lead Product Manager, RWE/Pharma (Fully Remote; US-Based)

Our Company Genomenon is an AI-driven biomedical intelligence company on a mission to save and improve lives by making biomedical information actionable. Rare diseases and cancer affect more than 30 million people in the U.S. alone and hundreds of millions globally, yet most patients still face long diagnostic journeys and limited treatment options. Our goal is clear and ambitious: to deliver the information that shapes diagnosis and treatment for every rare disease and cancer patient. We sit at the intersection of AI, genomics, and real world evidence. Genomenon transforms the global scientific literature into a literature derived, real world evidence (RWE) engine for precision medicine—combining large-scale AI with expert human curation to deliver clean, clinically actionable datasets. This approach fills critical gaps left by EHR and claims data, especially in rare disease and oncology, by showing how patients actually present, progress, and respond to therapy. We turn vast, complex biomedical data—spanning genomics, clinical evidence, and scientific literature—into trusted intelligence that helps clinicians make better diagnostic and therapeutic decisions, and supports life sciences organizations in bringing better therapies to market faster. Our work has real, measurable impact. Genomenon's platforms and services are used by more than 250 clinical laboratories and pharma organizations worldwide to support diagnostic interpretation, variant curation, and evidence-based decision-making across the drug development lifecycle. Each year, our technology helps inform care for tens of thousands of patients facing rare, complex, and time-sensitive conditions—reducing uncertainty and delivering answers when they matter most. What makes Genomenon unique is our ability to support both clinical diagnostics and pharmaceutical innovation on a shared foundation of advanced AI, deep domain expertise, and rigorously curated data. In the clinic, our solutions directly influence real world patient outcomes. • In pharma, we enable teams to harness literature derived RWE across clinical trial development, regulatory, and commercial workflows—turning fragmented biomedical knowledge into a strategic asset and emerging as the trusted data layer for genomic diagnostics and precision therapeutics. If you're motivated by impact, energized by complexity, and excited to help shape the future of rare disease diagnosis and treatment, there's no better place to do that work. Genomenon /ge.gno.mai.non/ Source language: ancient Greek • Verb to come into being to be born out of need • Noun the leader in genomic intelligence Our Community Genomenon team members are thoughtful, ambitious, and mission-driven professionals working across states and countries. Our team brings together scientists, clinicians, engineers, and commercial leaders who collaborate as equals and learn from one another every day. We value curiosity, accountability, and people who thrive in fast-moving, high-impact environments. We are guided by our core values: • Always Learning: Approach challenges with curiosity and a growth mindset • Data-Driven: Ask a lot of questions and look to the evidence for answers • Humbly Confident: Aware of the value that we and others bring to the team • Customer & Patient Driven: Put patients and customers first in everything we do • True Grit: Embody passion and persistence, and aren't afraid of hard work This role requires experience in Pharma and Real World Evidence. The Opportunity We're hiring a Senior Product Manager to own strategy and delivery for Genomenon's Literature-derived Real-World Evidence (RWE) data products and software platforms supporting rare disease and cancer diagnostics and drug development. You will partner with executive, engineering, scientific, data, and commercial teams to define product direction, translate customer and market needs into clear priorities, and ship solutions that are scientifically credible, commercially valuable, and measurable in impact. In this role, you will: • Set and drive product vision, roadmap, and quarterly priorities for our AI-driven real-world evidence products and expert-curated biomedical datasets • Lead planning and execution across the full product lifecycle (discovery requirements build launch iteration) • Align stakeholders and make tradeoffs across scale, speed, scientific rigor, and customer trust • Guide the work of a small, high-performing AI team and ensure engineering has clear, actionable requirements and success metrics • Evolve our hybrid model that combines AI and expert curation to meet pharma customer needs This role is ideal for a strategic, hands-on product leader with experience in real-world evidence and advanced AI applications in biomedicine who thrives in a fast-paced environment and wants to build mission-driven technology that improves patient outcomes. Position Responsibilities • Product Management • * Own strategy and delivery for AI-extracted real-w